You by no means hear “100%” in drugs. The trial was essentially the most profitable we’ve ever seen for HIV prevention. The drug was secure, too (it’s already authorized to deal with HIV infections). And it solely wanted to be injected twice a yr to supply full safety.
This week, the outcomes of a small section I trial for as soon as-yearly lenacapavir injections had been introduced at a convention in San Francisco. These early “first in human” trials are designed to check the protection of a drug in wholesome volunteers. Nonetheless, the outcomes are extremely promising: All of the volunteers nonetheless had the drug of their blood plasma a yr after their injections, and at ranges that earlier research recommend will defend them from HIV infections.
I don’t usually get too enthusiastic about section I trials, which normally contain only a handful of volunteers and sometimes don’t inform us a lot about whether or not a drug is prone to work. However this trial appears to be completely different. Collectively, the lenacapavir trials may deliver us a major step nearer to ending the HIV epidemic.
First, a fast recap. We’ve had efficient pre-exposure prophylactic (PrEP) medication for HIV since 2012, however these should be taken both every day or simply earlier than an individual is uncovered to the virus. In 2021, the US Meals and Drug Administration authorized the primary long-acting injectable drug for HIV prevention. That drug, cabotegravir, must be injected each two months.
However researchers have been engaged on medication that provide even longer-lasting safety. It may be troublesome for folks to recollect to take every day tablets after they’re sick, not to mention after they’re wholesome. And these medicines have a stigma connected to them. “Individuals are involved about folks listening to the tablets shake of their purse on the bus … or seeing them on a drugs cupboard or bedside desk,” says Moupali Das, vp of HIV prevention and virology, pediatrics, and HIV medical growth at Gilead Sciences.
